Breast- vs formula-feeding: Gut microbiota and inflammatory bowel disease. Effects of early environment on mucosal immunologic homeostasis, subsequent immune responses and disease outcome.
Our data provide further evidence suggesting that feeding with MBM masks the influence of varied degrees of immaturity of the gut at birth. Sanderson, W. A study showed an increased development of allergic disease in mice after oral antibiotic administration [ 27 ]. BM was collected with a sterile automatic BM pump with a vacuum regulator Medela Symphony, Barr, Switzerlandpolystyrene suction funnels and screw-top bottles adapted to suction funnels for the direct milk collection.
Inclusion criteria were based on early breastfeeding practices, no metabolic or chronic diseases and no probiotic consumption.
Clin Exp Allergy. Recruited mothers received detailed written information of the study and gave their signed informed consent to participate. Stool samples were collected daily while the infant was hospitalized, and weekly samples were analyzed for microbiome compositional differences using 16S rDNA-based sequencing.
The Impact of Breast-Feeding on Immediate and Long-Term Health-Effects Numerous studies have been performed in the last decades with the aim to define short- and long-term effects related to the initial microbial gut colonization.
Potential Protective Role Related to the Addiction of Prebiotics and Probiotics to Formula Food Because of the recognized healthy properties, exclusive breast-feeding has been recommended by the World Health Organization for the first 6 months of life and supplemental breast-feeding up to 2 years and beyond Le Huerou-Luron et al.
Initial Colonization and Host Defense Colonizing bacteria can act as an ancillary body organ. In studies from this laboratory 73we have identified a secreted product from the same B.
The microbiota consists of microorganisms: The Bifidogenic Effect of Breastfeeding For over 40 y, it has been known that breastfeeding, particularly in the first weeks of neonatal life, can stimulate the active proliferation of various strains of Bifidobacteria, e.
Individual infant trajectories lines for each infant are plotted along with box and whiskers for LME-modeled relative abundance values. Enterobacteriales specifically the Citrobacter and select Clostridiales specifically Clostridium, Ruminococcus, and Negativicoccus were identified as the best discriminators of MBM-fed infants.
Since no studies have been conducted to determine the influence of breast milk on intestinal colonization in preterm infants, we studied the composition of intestinal microbiota in preterm infants using three standard feeding regimes: Sudo et al.
The intestinal microbiota of infants is very different from the one of adults and shows very important inter-individual variability. Can nutritional modulation of maternal intestinal microbiota influence the development of the infant gastrointestinal tract?
A recent publication in Nature suggests that large families of microbiota, called enterotypes, evolve based on functional needs of the intestine, e. The Role of the Early Microbial Contact in Newborns In the development of the immune function, a pivotal role is played by the early microbial contact, that is likely to take place already in utero.
Although an important environmental factor in initial colonization, breastfeeding is not the only environmental factor involved and cannot, for example, account for inherent genetic defects. Breast Feeding, Breast Milk Microbiota and Their Influence on the Immune Function With respect to the gut barrier function, formula-fed infants showed a higher epithelial permeability compared with breastfed infants, independently of gestational age at the birth.
The most abundant phyla are Bacteroidetes and Firmicutes [ 10 ]. BM samples Mothers were received at a time frame between and hours at the hospital.
The intestinal microflora of infants: For example, in a recent study the Toll-like receptor-5 TLR-5 gene, located on the basolateral surface of intestinal enterocytes ligand-bacterial flagellawas knocked out, resulting in an altered intestinal microbiota leading to the phenotypic expression of obesity and metabolic syndrome Moreover, HMOs can be decorated with fucose or N-acetylneuraminic acid, mostly in terminal positions.
The development of immune function within the human intestine and its role in neonatal diseases. Nat Rev Immunol. Table S2 over time in the microbiome between the different infant feeding groups.microbiota could be modulated by probiotics in order to improve the microbiota of the mammary gland and increase the health supporting quality of the breast milk.
This in turn would have a direct effect on infant health.” Reference: 1. Fernández, Leónides et al. (): The human milk microbiota: Origin and potential roles in health and disease. Maternal breast-milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease.
Clin Exp Allergy. ; 37, – Cited by: · Conclusions. The preterm infant intestinal microbiome is influenced by postnatal time, birth weight, gestational age, and nutrition. Feeding with breast milk appears to mask the influence of birth weight, suggesting a protective effect against gut immaturity in the preterm elbfrollein.com by: Babies that are solely breast-fed until weaning have a microbiota dominated by bifidobacteria, whilst those that are formula-fed tend to have a more diverse microbiota.
Following the introduction of solid food to an infant diet, the microbiota changes and by the age of three the microbiota resembles a relatively stable, ‘healthy adult’-like composition .Cited by: · The breast milk influence on initial intestinal microbiota also prevents expression of immune-mediated diseases (asthma, inflammatory bowel disease, type 1 Cited by: Human breast milk itself contains oligosaccharides, functioning as prebiotics and also beneficial bacteria, which help in the maturation of the intestinal microbiota of the infant  [